Chemichemi Health Services
Creatinine Clearance
The creatinine clearance test is a key way to check how well the kidneys are filtering waste. It measures the rate at which creatinine, a natural by product of muscle metabolism, is cleared from blood into urine. Normal values are usually between 90–140 mL/min/1.73 m² in adults. The test estimates glomerular filtration rate (GFR), which reflects kidney function. Creatinine is produced at a steady rate by muscles and is normally filtered by the kidneys. If the kidneys are not working well, creatinine builds up in the blood. Clinicians use this test to detect early kidney disease, monitor progression, and adjust medication doses that depend on kidney clearance.
How the Test is Done
Urine is collected over a 24 hour period. A blood test is taken to measure serum creatinine concentration.  The laboratory compares urine creatinine concentration, urine volume, and blood creatinine to calculate clearance in millilitres per minute per 1.73 m² body surface area (mL/min/1.73 m²).
Reference Values
Group                 Normal Range (mL/min/1.73 m²)
Adult men          100–140
Adult women    90–130
Elderly Values decline naturally with age. Children Higher relative values due to growth. Values below 60 mL/min/1.73 m² may suggest chronic kidney disease, while values above 140 can occur in pregnancy or with high muscle mass.
Patient Preparation Tips
• Hydration: Drink your usual amount of fluids; avoid excessive intake.
• Diet: Stick to your normal diet; avoid large amounts of meat before the test, as this can raise creatinine.
• Medications: Inform your doctor about any medicines you are taking, especially antibiotics or drugs affecting kidney function.
• Accuracy: Ensure all urine is collected during the 24 hour period; missing samples can make results unreliable.
What Results Mean
• Normal clearance: Kidneys are effectively filtering waste.
• Reduced clearance: May indicate kidney disease, dehydration, or obstruction.
• Elevated clearance: Sometimes seen in pregnancy or with increased muscle mass.
Important Considerations
• This test is more accurate than serum creatinine alone but can be affected by incomplete urine collection.
• A repeat the test or use other measures like estimated GFR (eGFR) may be included for confirmation.
The creatinine clearance test is a practical way to assess kidney health. By carefully following instructions for urine collection and blood sampling, patients help ensure reliable results that guide clinicians in diagnosis and treatment.
Proteinuria

 Protein Test in Urine (Proteinuria)

A urine protein test measures the concentration of protein in urine. Normally, kidneys filter waste products while retaining proteins such as albumin in the blood.  Proteinuria, it may signal kidney damage or other health problems. Protein concentration in urine is usually reported in grams per liter (g/L) or milligrams per deciliter (mg/dL). For 24‑hour urine collections, results are expressed as grams per 24 hours (g/24 h).

Reference ranges

  1. Spot urine sample: < 0.15 g/L (150 mg/L)
  2. 24‑hour urine collection: < 0.15 g/24 h
  3. Albumin-to-creatinine ratio (ACR): < 3 mg/mmol

Monitoring helps track progression in patients with diabetes, hypertension, or chronic kidney disease. Proteinuria can be the first sign of kidney disease. Diagnosis Identifies causes such as infections, autoimmune disorders, or cardiovascular disease.

Indications for the test include; diabetes mellitus (risk of diabetic nephropathy), high blood pressure, family history of kidney disease and people experiencing swelling (edema), foamy urine, or unexplained fatigue.

The test is done with a random urine sample,  a quick test, often used for screening; 24‑hour urine collection which measures total protein excretion over a day; Albumin-to-creatinine ratio (ACR), a more precise test that adjusts for urine concentration.

Interpretation of Results

Result  Value Possible Meaning
Normal < 0.15 g/L or < 0.15 g/24 h Healthy kidney function
Mild proteinuria 0.15–0.5 g/24 h Early kidney stress, hypertension, diabetes
Moderate proteinuria 0.5–3.0 g/24 h Chronic kidney disease, glomerulonephritis
Severe proteinuria > 3.0 g/24 h Nephrotic syndrome, advanced kidney damage

 

Blood urea

The urea test (often called the Blood Urea Nitrogen or BUN test) measures the amount of urea nitrogen in blood to check how well your kidneys and liver are working. Urea is a waste product formed in the liver when the body breaks down protein. The kidneys filter urea from the blood and excrete it in urine. A urea test (or BUN test) measures the concentration of urea nitrogen in the blood to assess kidney and liver function.

The test is used to: Evaluate kidney health and detect kidney disease; Monitor liver function since urea is produced in the liver; Check protein metabolism in the body; Investigate symptoms like fatigue, swelling, or changes in urination; Monitor chronic conditions such as diabetes, hypertension, or heart disease.

Reference Ranges

  • Adults: 7–20 mg/dL (may vary slightly by lab).
  • Children: Lower ranges are common.
  • Older adults: Levels may be slightly higher.
    (Always check with your health provider for lab-specific ranges.)

High urea levels may indicate kidney disease, dehydration, high protein intake, or heart failure. Low urea levels could suggest liver disease, malnutrition, or overhydration. BUN-to-creatinine ratio is often measured together to give a clearer picture of kidney function.

Urinalysis

Urine Test (Urinalysis)

A urine test (urinalysis) is a simple, non-invasive test that examines the content and appearance of urine to help detect a wide range of health conditions, including infections, kidney disease, diabetes, and liver problems. A urine test or urinalysis involves analyzing a urine sample to check for substances that may indicate disease. It is one of the most common diagnostic tests because urine reflects how the body is functioning and can reveal problems in the kidneys, urinary tract, liver, and metabolism. The test is quick, painless, and often part of routine health check-ups.

The test is used to; Detect urinary tract infections (UTIs); Monitor kidney function and detect kidney disease; Screen for diabetes (by checking glucose levels); Assess liver function (bilirubin in urine); Detect blood in urine (hematuria); Monitor hydration status and overall health; Check for drug use or pregnancy (specialized urine tests).

 Types of Urine Tests

  1. Visual Examination
    • Checks color, clarity, and odor.
    • Normal urine is pale yellow and clear.
    • Cloudy or dark urine may indicate infection, dehydration, or liver disease.
  2. Dipstick Test
    • A chemically treated strip is dipped into urine.
    • Detects pH, protein, glucose, ketones, blood, bilirubin, nitrites, and leukocytes.
    • Results are semi-quantitative.
  3. Microscopic Examination
    • Urine is examined under a microscope.
    • Identifies cells, crystals, bacteria, or casts (structures formed in kidney tubules).
  4. 24-Hour Urine Collection
    • Measures substances over a full day (e.g., creatinine, protein, electrolytes).
    • Provides more accurate assessment of kidney function.

Typical values (may vary by lab):

Parameter Reference Ranges
pH 4.5 – 8.0
Specific Gravity 1.005 – 1.030
Protein <150 mg/day (≈ <0.15 g/day)
Glucose Negative
Ketones Negative
Bilirubin Negative
Urobilinogen 0.2 – 1.0 mg/dL (≈ 3.5 – 17 µmol/L)
Creatinine (24h urine) Men: 7–18 mmol/day; Women: 5–16 mmol/day

Protein in urine (proteinuria) may indicate kidney disease. Glucose in urine (glycosuria) suggests diabetes. Blood in urine could be due to infection, stones, or more serious conditions. High bilirubin may signal liver disease or bile duct obstruction. Abnormal pH can reflect infection or metabolic imbalance.

Urine tests are simple, inexpensive, and highly informative. They provide valuable insights into kidney, liver, and metabolic health. Abnormal results don’t always mean disease but should be interpreted by a healthcare professional in the context of your overall health.

Creatinine Test

Creatinine is a natural waste product produced in the muscles during the breakdown of a compound called creatine, which plays a key role in energy production. Because muscles produce creatinine at a relatively constant rate, and kidneys are responsible for filtering it out of the bloodstream, measuring creatinine levels provides valuable information about how well the kidneys are functioning.

A creatinine test measures the amount of creatinine in the blood and/or urine. Since healthy kidneys are highly effective at removing creatinine from the body, elevated levels in the blood often indicate impaired kidney function. Conversely, low levels in urine may signal the that the kidneys are failing to filter waste properly.

Creatinine testing evaluate different aspects of the body’s metabolic and organ function and are frequently used during routine checkups, emergency evaluations, and hospital admissions. In some cases, creatinine is also included in a specialized renal panel, which focuses specifically on kidney health.

The creatinine test is usually ordered together with Blood Urea Nitrogen (BUN). While creatinine reflects muscle metabolism, BUN measures urea, a waste product from protein metabolism. Evaluating these two together helps clinicians gain a more complete picture of kidney performance.

A high creatinine level, especially when accompanied by an elevated BUN, can point to; Acute kidney injury; Chronic kidney disease; Dehydration; Kidney infections or blockages; Conditions affecting blood flow to the kidneys

Creatinine test may be requested  in: kidney disease, such as swelling, fatigue, or changes in urination; chronic illnesses known to damage kidneys, including diabetes, high blood pressure, or heart disease; those taking medications that may affect kidney function patients scheduled for imaging procedures like a CT scan or MRI that require contrast dyes which can be harmful if the kidneys are not working properly; monitoring to track the progression of kidney disease or response to treatment.

Kidneys are involved in the filtering of toxins and waste products from the blood. If they are not working well, creatinine builds up in the bloodstream. Early detection through routine creatinine testing can help prevent serious complications, including: Kidney failure; Fluid imbalance; Electrolyte disturbances; Cardiovascular complications. Individuals with chronic conditions, regular creatinine and BUN testing helps ensure timely adjustments in medication, diet, and overall treatment plans.

The test is a simple powerful tool used to evaluate  kidney health. Whether as part of a routine checkup, an emergency evaluation, or ongoing monitoring, it provides crucial insight into how effectively kidneys are filtering waste. Keeping creatinine levels within a healthy range is essential to overall well-being. The use of creatinine in early detection of kidney problems therefore can make treatment more effective.